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Antibody mutations favoring pH-dependent binding in solid tumor microenvironments: Insights from large-scale structure-based calculations.

Proteins - 1 Aug 2022

Wei Wanlei, Corbeil Christopher R, Gaudreault Francis, Deprez Christophe, Purisima Enrico O, Sulea Traian

Abstract excerpt

Antibody-based therapeutics for treatment of various tumors have grown rapidly in recent years. Unfortunately, safety issues, attributed to off-tumor effects and cytotoxicity, are still a significant concern with the standard of care. Improvements to ensure targeted delivery of antitumor pharmaceuticals are desperately needed. We previously demonstrated that incorporating histidyl pH-switches in an anti-HER2...

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PMID: 35355327
DOI: 10.1002/prot.26340

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