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Article

Tumorspheres but not adherent cells derived from retinoblastoma tumors are of malignant origin.

PloS one - 1 Jan 2013

Bond Wesley S, Akinfenwa Patricia Y, Perlaky Laszlo, Hurwitz Mary Y, Hurwitz Richard L, Chévez-Barrios Patricia

Abstract excerpt

Verification that cell lines used for cancer research are derived from malignant cells in primary tumors is imperative to avoid invalidation of study results. Retinoblastoma is a childhood ocular tumor that develops from loss of functional retinoblastoma protein (pRb) as a result of genetic or epigenetic changes that affect both alleles of the RB1 gene. These patients contain unique identifiable genetic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 23826078
DOI: 10.1371/journal.pone.0063519
PMCID: PMC3691222

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Source receipt: pubmed, retrieved 7 Sept 2026.

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