Newly established human retinoblastoma cell lines exhibit an "immortalized" but not an invasive phenotype in vitro.

doi:10.1002/ijc.2910460123

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Article

Newly established human retinoblastoma cell lines exhibit an "immortalized" but not an invasive phenotype in vitro.

International journal of cancer - 15 Jul 1990

Griegel S, Hong C, Frötschl R, Hülser D F, Greger V, Horsthemke B, Rajewsky M F

Abstract excerpt

Retinoblastoma (RB), an intraocular childhood tumor occurring in a hereditary (mostly bilateral) or non-hereditary (unilateral) form, is associated with the inactivation of both alleles of a putative tumor suppressor gene (RB-I) located on chromosome 13q14. Both the process of RB development and...

Topics

Animals
Cell Line
Cell Line, Transformed
Cell Transformation, Viral
Chick Embryo
DNA, Neoplasm
DNA, Viral
Eye Neoplasms
Gene Amplification
Humans
Mice
Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Invasiveness

Neoplasm Transplantation

Oncogenes

Phenotype

Retinoblastoma

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 2365495
DOI: 10.1002/ijc.2910460123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2365495-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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