Generation of cell lines to study the role played by oncogenes and anti-oncogenes in cell proliferation control.

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Article

Generation of cell lines to study the role played by oncogenes and anti-oncogenes in cell proliferation control.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jan 1990

Costanzi E, Rameh L E, Joazeiro C A, Armelin M C

Abstract excerpt

We report the generation of stable transfectant cell lines by DNA-mediated transfection that overexpress viral and/or cellular oncogenes. Expression of heterologous genes (FBJ- and FBR-v-fos, polyoma large and middle T) was confirmed by Northern hybridization, immunofluorescence and immunoprecipi...

Topics

Cell Division
Cell Line, Transformed
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Oncogenes
Phenotype
Retinoblastoma
Transfection

Source

Open in PubMed

Identifiers

PMID: 2101319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2101319-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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