Article
Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss.
Audiology & neuro-otology - 1 Jan 2000
Ohlemiller K K, McFadden S L, Ding D L, Flood D G, Reaume A G, Hoffman E K, Scott R W, Wright J S, Putcha G V, Salvi R J
Abstract excerpt
Reactive oxygen species (ROS) such as superoxide, peroxide and hydroxyl radicals are generated during normal cellular metabolism and are increased in acute injury and in many chronic disease states. When their production is inadequately regulated, ROS accumulate and irreversibly damage cell components, causing impaired cellular function and death. Antioxidant enzymes such as superoxide dismutase (SOD) play a...
Topics
- Alleles
- Animals
- Auditory Threshold
- Evoked Potentials, Auditory, Brain Stem
- Female
- Gene Amplification
- Gene Deletion
- Genetic Predisposition to Disease
- Genotype
- Hair Cells, Auditory
- Hearing Loss, Noise-Induced
- Male
- Mice