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Article

Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction.

Journal of neurochemistry - 1 Aug 2018

Morioka Shigefumi, Sakaguchi Hirofumi, Yamaguchi Taro, Ninoyu Yuzuru, Mohri Hiroaki, Nakamura Takashi, Hisa Yasuo, Ogita Kiyokazu, Saito Naoaki, Ueyama Takehiko

Abstract excerpt

Previous studies have convincingly argued that reactive oxygen species (ROS) contribute to the development of several major types of sensorineural hearing loss, such as noise-induced hearing loss (NIHL), drug-induced hearing loss, and age-related hearing loss. However, the underlying molecular mechanisms induced by ROS in these pathologies remain unclear. To resolve this issue, we established an in vivo model of...

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PMID: 29675997
DOI: 10.1111/jnc.14451

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NOX4

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