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Article

Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss.

Clinical chemistry - 1 Nov 2004

Fortunato Giuliana, Marciano Elio, Zarrilli Federica, Mazzaccara Cristina, Intrieri Mariano, Calcagno Giuseppe, Vitale Dino F, La Manna Paolo, Saulino Claudio, Marcelli Vincenzo, Sacchetti Lucia

Abstract excerpt

BACKGROUND: Noise-induced cochlear epithelium damage can cause hearing loss in industrial workers. In experimental systems, noise induces the release of free radicals and may damage the cochlear sensorial epithelium. Therefore, genes involved in regulating the reactive oxygen species manganese-superoxide dismutase (SOD2) and the antioxidant paraoxonase (PON) could influence cochlea vulnerability to noise. We...

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Source

Identifiers

PMID: 15345661
DOI: 10.1373/clinchem.2004.037788

Genes

SOD2
PON1
PON2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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