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Article

Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase.

Neurobiology of aging - 1 Jan 2000

McFadden S L, Ding D, Reaume A G, Flood D G, Salvi R J

Abstract excerpt

Age-related hearing loss in humans and many strains of mice is associated with a base-to-apex gradient of cochlear hair cell loss. To determine if copper/zinc superoxide dismutase (Cu/Zn SOD) deficiency influences age-related cochlear pathology, we compared hair cell losses in cochleas obtained from 2-, 7-, and 17- to 19-month-old wild type (WT) mice with normal levels of Cu/Zn SOD and mutant knockout (KO) mice...

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Source

Identifiers

PMID: 10466888
DOI: 10.1016/s0197-4580(99)00018-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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