FOXA2 Transcriptionally Activates SIRT1 to Inhibit Cochlear Ferroptosis in Noise-Induced Hearing Loss.

doi:10.3390/genes17080953

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FOXA2 Transcriptionally Activates SIRT1 to Inhibit Cochlear Ferroptosis in Noise-Induced Hearing Loss.

Genes - 14 Aug 2026

Dai Xiaoru, Sun Peng, Jiang Minyun, Xie Lizhuang, Zhang Hengdong, Zhu Baoli, Wang Boshen

Abstract excerpt

Background: Noise-induced hearing loss (NIHL) is a pervasive occupational health challenge, yet the individual susceptibility mechanisms remain unclear. Ferroptosis, an iron-dependent form of programmed cell death, has been implicated in cochlear hair cell damage. This study aims to elucidate the regulatory role of the transcription factor FOXA2 and the deacetylase SIRT1 in ferroptosis and to investigate the...

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Case-Control Studies
Ferroptosis
Hair Cells, Auditory
Hearing Loss, Noise-Induced
Hepatocyte Nuclear Factor 3-beta
Mice
Mice, Inbred C57BL

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Sirtuin 1

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Open in PubMed Open full text

Identifiers

PMID: 42650146
DOI: 10.3390/genes17080953
PMCID: PMC13511884

Genes

SIRT1
FOXA2
GPX4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.