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Article

Anatomical, metabolic and genetic aspects of age-related hearing loss in mice.

Audiology : official organ of the International Society of Audiology - 1 Jan 2000

McFadden S L, Ding D, Salvi R

Abstract excerpt

Because of their short lifespan and genetic homogeneity, mice can provide valuable insights into the biological basis of age-related hearing loss. In C57BL/6 mice, hair cell loss begins around 1-2 months of age and progresses rapidly along a base-to-apex gradient, whereas CBA mice show relatively little hair cell loss until late in life. This anatomical difference is reflected in dehydrogenase histochemistry, an...

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Source

Identifiers

PMID: 11781044

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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