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Article

Determinants of voltage-dependent gating and open-state stability in the S5 segment of Shaker potassium channels.

The Journal of general physiology - 1 Aug 1999

Kanevsky M, Aldrich R W

Abstract excerpt

The best-known Shaker allele of Drosophila with a novel gating phenotype, Sh(5), differs from the wild-type potassium channel by a point mutation in the fifth membrane-spanning segment (S5) (Gautam, M., and M.A. Tanouye. 1990. Neuron. 5:67-73; Lichtinghagen, R., M. Stocker, R. Wittka, G. Boheim, W. Stühmer, A. Ferrus, and O. Pongs. 1990. EMBO [Eur. Mol. Biol. Organ.] J. 9:4399-4407) and causes a decrease in the...

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Identifiers

PMID: 10435999
DOI: 10.1085/jgp.114.2.215
PMCID: PMC2230647

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Determinants of voltage-dependent gating and open-state stability in the S5 segment of Shaker potassium channels.PMID 10435999Read ↗

Alterations in activation gating of single Shaker A-type potassium channels by the Sh5 mutation.Semantic proximity Read ↗

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.Semantic proximity Read ↗

Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels.Semantic proximity Read ↗

Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster.Semantic proximity Read ↗

Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation.Semantic proximity Read ↗

Non-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating.Semantic proximity Read ↗

Role of the S3-S4 linker in Shaker potassium channel activation.Semantic proximity Read ↗

The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.Semantic proximity Read ↗

Alteration of potassium channel gating: molecular analysis of the Drosophila Sh5 mutation.Semantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.Semantic proximity Read ↗

The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects.Semantic proximity Read ↗

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