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Article

Alterations in activation gating of single Shaker A-type potassium channels by the Sh5 mutation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jun 1990

Zagotta W N, Aldrich R W

Abstract excerpt

Alterations in voltage-dependent gating of A-type potassium channels by the Sh5 mutation were studied using macroscopic and single-channel recording techniques on cultured embryonic myotubes from Drosophila. The mutation increases the voltage required to activate and inactivate the A1 channel by approximately 20 mV and decreases the steepness of the voltage dependence of steady-state inactivation. Boltzmann fits...

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PMID: 2355250
PMCID: PMC6570318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alterations in activation gating of single Shaker A-type potassium channels by the Sh5 mutation.PMID 2355250Read ↗

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Episodic ataxia/myokymia mutations functionally expressed in the Shaker potassium channel.Semantic proximity Read ↗

Non-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating.Semantic proximity Read ↗

Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels.Semantic proximity Read ↗

How does the W434F mutation block current in Shaker potassium channels?Semantic proximity Read ↗

Characterization of five RNA editing sites in Shab potassium channels.Semantic proximity Read ↗

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A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels.Semantic proximity Read ↗

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