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Article

Role of the S3-S4 linker in Shaker potassium channel activation.

The Journal of general physiology - 1 Feb 1997

Mathur R, Zheng J, Yan Y, Sigworth F J

Abstract excerpt

Structural models of voltage-gated channels suggest that flexibility of the S3-S4 linker region may be important in allowing the S4 region to undergo large conformational changes in its putative voltage-sensing function. We report here the initial characterization of 18 mutations in the S3-S4 linker of the Shaker channel, including deletions, insertions, charge change, substitution of prolines, and chimeras...

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Identifiers

PMID: 9041448
DOI: 10.1085/jgp.109.2.191
PMCID: PMC2220058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Role of the S3-S4 linker in Shaker potassium channel activation.PMID 9041448Read ↗

Modulation of the Shaker K(+) channel gating kinetics by the S3-S4 linker.Semantic proximity Read ↗

S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel.Semantic proximity Read ↗

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.Semantic proximity Read ↗

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.Semantic proximity Read ↗

Determinants of voltage-dependent gating and open-state stability in the S5 segment of Shaker potassium channels.Semantic proximity Read ↗

The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.Semantic proximity Read ↗

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.Semantic proximity Read ↗

Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation.Semantic proximity Read ↗

Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.Semantic proximity Read ↗

Non-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating.Semantic proximity Read ↗

Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.Semantic proximity Read ↗

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.Semantic proximity Read ↗

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