Article
Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster.
The EMBO journal - 1 Dec 1990
Lichtinghagen R, Stocker M, Wittka R, Boheim G, Stühmer W, Ferrus A, Pongs O
Abstract excerpt
Mutations in the Shaker (Sh) locus of Drosophila melanogaster have differing effects on action potential duration and repolarization in neurons as well as on A-type K+ channels (IA) in muscle. The molecular basis of three exemplary Sh alleles (ShKS133, ShE62 and Sh5) has been identified. They are point mutations in the Sh transcription unit expressing aberrant voltage-gated A-type K+ channels. Replicas of each...
Topics
- Action Potentials
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA
- Drosophila melanogaster
- Molecular Sequence Data
- Muscles
- Mutation
- Neurons
- Oocytes
- Potassium Channels