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Article

Tubulointerstitial disease in aging: evidence for underlying peritubular capillary damage, a potential role for renal ischemia.

Journal of the American Society of Nephrology : JASN - 1 Feb 1998

Thomas S E, Anderson S, Gordon K L, Oyama T T, Shankland S J, Johnson R J

Abstract excerpt

Aging is associated with a progressive decline in renal function and the development of glomerulosclerosis and interstitial fibrosis. Although many studies have addressed the cellular mechanisms of age-related glomerulosclerosis, less is known about the tubulointerstitial fibrosis. In this study, aging (24 mo) rats develop tubulointerstitial fibrosis characterized by tubular injury and focal tubular cell...

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PMID: 9527399
DOI: 10.1681/ASN.V92231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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