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Article

Substitution of the insulin receptor transmembrane domain with that of glycophorin A inhibits insulin action.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 1999

Gardin A, Auzan C, Clauser E, Malherbe T, Aunis D, Crémel G, Hubert P

Abstract excerpt

To study the role of transmembrane (TM) domains interactions in the activation of the insulin receptor, we have replaced the insulin receptor TM domain with that of glycophorin A (GpA), an erythrocyte protein that spontaneously forms detergent-resistant dimers through TM-TM interactions. Insulin receptor cDNA sequences with the TM domain replaced by that of GpA were constructed and stably transfected in CHO...

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PMID: 10428759
DOI: 10.1096/fasebj.13.11.1347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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