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Article

Insulin/IGF-I receptor hybrids: a mechanism for increasing receptor diversity.

Journal of cellular biochemistry - 1 Feb 1992

Moxham C P, Jacobs S

Abstract excerpt

Insulin and IGF-I receptors are homologous disulfide linked alpha 2 beta 2 tetramers. These tetramers are formed biosynthetically when proreceptors containing alpha and beta subunits in a single uninterrupted linear peptide form disulfide linked homodimers and are subsequently proteolytically cleaved at the alpha-beta junctions. Cells expressing both receptors also express hybrid receptors that contain one...

Topics

Animals
Cells, Cultured
Humans
Insulin-Like Growth Factor I
Mutation
Phosphorylation
Receptor, Insulin
Receptors, Cell Surface
Receptors, Somatomedin

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1320041
DOI: 10.1002/jcb.240480205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1320041-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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