Article
Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system.
Endocrinology - 1 Mar 1996
Tartare-Deckert S, Murdaca J, Sawka-Verhelle D, Holt K H, Pessin J E, Van Obberghen E
Abstract excerpt
Activation of the phosphatidyl inositol 3-kinase (PI 3-kinase) is one of the immediate events in signaling by the insulin receptor (IR) and the insulin-like growth factor-1 receptor (IGF-IR). The IR and IGF-IR are two closely related tyrosine kinases, which are activated on binding of their respe...
Topics
- Mutation
- Phosphotransferases (Alcohol Group Acceptor)
- Receptor, IGF Type 1
- Receptor, Insulin
- Recombinant Proteins
- Saccharomyces cerevisiae