Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.

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Article

Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.

The Journal of biological chemistry - 11 Mar 1994

Wertheimer E, Barbetti F, Muggeo M, Roth J, Taylor S I

Abstract excerpt

Insulin initiates its biological response by binding to the extracellular domain of the insulin receptor. The N-terminal half of the alpha-subunit contains several repeats of a loosely conserved motif consisting of a central glycine plus several hydrophobic amino acid residues upstream from the g...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Base Sequence
Biological Transport
Conserved Sequence
Glycine
Humans
Insulin Resistance
Mice
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Phosphorylation

Protein Folding

Receptor, Insulin

Receptors, Cell Surface

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 8125981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8125981-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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