Structure and function of the insulin receptor-a personal perspective.

doi:10.2183/pjab.95.039

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Structure and function of the insulin receptor-a personal perspective.

Proceedings of the Japan Academy. Series B, Physical and biological sciences - 1 Jan 2019

Kasuga Masato

Abstract excerpt

Immunoprecipitation with autoantibodies to the insulin receptor derived from patients with extreme insulin resistance and acanthosis nigricans revealed that the receptor is comprised of two subunits of 135 kDa (α subunit) and 95 kDa (β subunit) and that insulin induces the rapid phosphorylation of the β subunit in intact cells. Incubation of a highly purified insulin receptor preparation with [γ-32P]ATP also...

Topics

Adenosine Triphosphate
Amino Acid Sequence
Animals
Binding Sites
Humans
Insulin
Insulin Resistance
Mutation
Phosphorylation
Protein Binding
Protein-Tyrosine Kinases
Receptor, Insulin
Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 31827016
DOI: 10.2183/pjab.95.039
PMCID: PMC6920081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics