Article
Decreased phosphorylation of mutant insulin receptor by protein kinase C and protein kinase A.
The Journal of biological chemistry - 30 Jun 1995
Miele C, Formisano P, Sohn K J, Caruso M, Pianese M, Palumbo G, Beguino L, Beguinot F
Abstract excerpt
We have recently reported that the Arg1152-->Gln insulin receptor mutation (QK single mutant) alters a conserved motif (RK motif) immediately next to the key tyrosine phosphorylation sites (Tyr1146, Tyr1150, Tyr1151) of the receptor and constitutively activates its kinase and metabolic signaling....
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Cyclic AMP-Dependent Protein Kinases
- Insulin
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Kinase C
- Receptor, Insulin