Reaction phenotyping: current industry efforts to identify enzymes responsible for metabolizing drug candidates.

Abstract excerpt

Reaction phenotyping studies to identify specific enzymes involved in the metabolism of drug candidates are increasingly important in drug discovery efforts. Experimental approaches used for CYP reaction phenotyping include incubations with cDNA expressed CYP enzyme systems and incubations containing specific CYP enzyme inhibitors. Since both types of experiments present specific advantages as well as known...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cytochrome P-450 Enzyme System
• Share to Drug Industry
• Share to Pharmaceutical Preparations