Article
Divergent evolution of membrane protein topology: the Escherichia coli RnfA and RnfE homologues.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 1999
Sääf A, Johansson M, Wallin E, von Heijne G
Abstract excerpt
Although the molecular evolution of protein tertiary structure and enzymatic activity has been studied for decades, little attention has been paid to the evolution of membrane protein topology. Here, we show that two closely related polytopic inner membrane proteins from Escherichia coli have evolved opposite orientations in the membrane, which apparently has been achieved by the selective redistribution of...
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