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Article

Emulating membrane protein evolution by rational design.

Science (New York, N.Y.) - 2 Mar 2007

Rapp Mikaela, Seppälä Susanna, Granseth Erik, von Heijne Gunnar

Abstract excerpt

How do integral membrane proteins evolve in size and complexity? Using the small multidrug-resistance protein EmrE from Escherichia coli as a model, we experimentally demonstrated that the evolution of membrane proteins composed of two homologous but oppositely oriented domains can occur in a sma...

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PMID: 17255477
DOI: 10.1126/science.1135406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17255477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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