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Article

Reversible topological organization within a polytopic membrane protein is governed by a change in membrane phospholipid composition.

The Journal of biological chemistry - 12 Dec 2003

Zhang Wei, Bogdanov Mikhail, Pi Jing, Pittard A James, Dowhan William

Abstract excerpt

Once inserted, transmembrane segments of polytopic membrane proteins are generally considered stably oriented due to the large free energy barrier to topological reorientation of adjacent extramembrane domains. However, the topology and function of the polytopic membrane protein lactose permease...

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PMID: 14525982
DOI: 10.1074/jbc.M309840200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14525982-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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