Article
Arrangements in the modular evolution of proteins.
Trends in biochemical sciences - 1 Sept 2008
Moore Andrew D, Björklund Asa K, Ekman Diana, Bornberg-Bauer Erich, Elofsson Arne
Abstract excerpt
It has been known for the last couple of decades that proteins evolve partly through rearrangements of larger fragments, typically domains. These units are considered the basic modules of protein structure, evolution and function. In the last few years, the analysis of protein-domain rearrangements has provided us with functional and evolutionary insights and has aided improved functional predictions and domain...
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