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Article

Small-residue packing motifs modulate the structure and function of a minimal de novo membrane protein.

Scientific reports - 16 Sept 2020

Curnow Paul, Hardy Benjamin J, Dufour Virginie, Arthur Christopher J, Stenner Richard, Hodgson Lorna R, Verkade Paul, Williams Christopher, Shoemark Deborah K, Sessions Richard B, Crump Matthew P, Jones Michael R, Anderson J L Ross

Abstract excerpt

Alpha-helical integral membrane proteins contain conserved sequence motifs that are known to be important in helix packing. These motifs are a promising starting point for the construction of artificial proteins, but their potential has not yet been fully explored. Here, we study the impact of introducing a common natural helix packing motif to the transmembrane domain of a genetically-encoded and structurally...

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Identifiers

PMID: 32938984
DOI: 10.1038/s41598-020-71585-8
PMCID: PMC7495484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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