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Article

Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Aug 1999

Schwartz D C, Parker R

Abstract excerpt

The turnover of most mRNAs in Saccharomyces cerevisiae begins with deadenylation followed by decapping and 5'-->3' exonucleolytic digestion. An important question involves the mechanisms that allow particular mRNAs to exhibit different rates of both deadenylation and decapping. Since the cap structure plays a critical role in the assembly of translation initiation factors, we hypothesized that the status of the...

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Identifiers

PMID: 10409716
DOI: 10.1128/MCB.19.8.5247
PMCID: PMC84368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae.PMID 10409716Read ↗

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mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E.Semantic proximity Read ↗

Premature translational termination triggers mRNA decapping.Semantic proximity Read ↗

Analysis of mutations in the yeast mRNA decapping enzyme.Semantic proximity Read ↗

Modulation of eukaryotic mRNA stability via the cap-binding translation complex eIF4F.Semantic proximity Read ↗

Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Tethering of poly(A)-binding protein interferes with non-translated mRNA decay from the 5' end in yeast.Semantic proximity Read ↗

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Targeted mRNA degradation by deadenylation-independent decapping.Semantic proximity Read ↗

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