Article
Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Aug 1999
Schwartz D C, Parker R
Abstract excerpt
The turnover of most mRNAs in Saccharomyces cerevisiae begins with deadenylation followed by decapping and 5'-->3' exonucleolytic digestion. An important question involves the mechanisms that allow particular mRNAs to exhibit different rates of both deadenylation and decapping. Since the cap structure plays a critical role in the assembly of translation initiation factors, we hypothesized that the status of the...
Topics
- Endoribonucleases
- Exoribonucleases
- Fungal Proteins
- Half-Life
- Macromolecular Substances
- Mutation
- Peptide Chain Initiation, Translational
- Peptide Initiation Factors
- RNA Cap-Binding Proteins
- RNA Caps
- RNA, Fungal
- RNA, Messenger
- RNA-Binding Proteins
- Saccharomyces cerevisiae