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Article

Analysis of mutations in the yeast mRNA decapping enzyme.

Genetics - 1 Apr 1999

Tharun S, Parker R

Abstract excerpt

A major mechanism of mRNA decay in yeast is initiated by deadenylation, followed by mRNA decapping, which exposes the transcript to 5' to 3' exonucleolytic degradation. The decapping enzyme that removes the 5' cap structure is encoded by the DCP1 gene. To understand the function of the decapping...

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Identifiers

PMID: 10101156
DOI: 10.1093/genetics/151.4.1273
PMCID: PMC1460575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10101156-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Analysis of mutations in the yeast mRNA decapping enzyme.PMID 10101156Read ↗

Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae.Semantic proximity Read ↗

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mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E.Semantic proximity Read ↗

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif.Semantic proximity Read ↗

Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human.Semantic proximity Read ↗

New insights into the control of mRNA decapping.Semantic proximity Read ↗

Mutations in the Saccharomyces cerevisiae LSM1 gene that affect mRNA decapping and 3' end protection.Semantic proximity Read ↗

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Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.Semantic proximity Read ↗

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