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Article

Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Oct 1996

Hatfield L, Beelman C A, Stevens A, Parker R

Abstract excerpt

The decay of several yeast mRNAs occurs by a mechanism in which deadenylation precedes decapping and subsequent 5'-to-3' exonucleolytic decay. In order to identify gene products required for this process of mRNA turnover, we screened a library of temperature-sensitive strains for mutants with altered mRNA degradation. We identified seven mutations in four genes that inhibited mRNA turnover. Two mutations were...

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Identifiers

PMID: 8816497
DOI: 10.1128/MCB.16.10.5830
PMCID: PMC231584

Genes

XRN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae.PMID 8816497Read ↗

Analysis of mutations in the yeast mRNA decapping enzyme.Semantic proximity Read ↗

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif.Semantic proximity Read ↗

Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs.Semantic proximity Read ↗

Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in VPS16 and MRT1 stabilize mRNAs by activating an inhibitor of the decapping enzyme.Semantic proximity Read ↗

Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain.Semantic proximity Read ↗

Yeast Sm-like proteins function in mRNA decapping and decay.Semantic proximity Read ↗

Stm1 modulates mRNA decay and Dhh1 function in Saccharomyces cerevisiae.Semantic proximity Read ↗

mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E.Semantic proximity Read ↗

Scavenger decapping activity facilitates 5' to 3' mRNA decay.Semantic proximity Read ↗

Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae.Semantic proximity Read ↗

The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1.Semantic proximity Read ↗

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