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Article

Tethering of poly(A)-binding protein interferes with non-translated mRNA decay from the 5' end in yeast.

The Journal of biological chemistry - 29 Oct 2010

Tsuboi Tatsuhisa, Inada Toshifumi

Abstract excerpt

The decay of eukaryotic mRNA is triggered mainly by deadenylation, which leads to decapping and degradation from the 5' end of an mRNA. Poly(A)-binding protein has been proposed to inhibit the decapping process and to stabilize mRNA by blocking the recruitment of mRNA to the P-bodies where mRNA degradation takes place after stimulation of translation initiation. In contrast, several lines of evidence show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20732870
DOI: 10.1074/jbc.M110.117150
PMCID: PMC2962457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tethering of poly(A)-binding protein interferes with non-translated mRNA decay from the 5' end in yeast.PMID 20732870Read ↗

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