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Article

Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme.

Nucleic acids research - 1 May 1998

Schwer B, Mao X, Shuman S

Abstract excerpt

Current models of mRNA decay in yeast posit that 3' deadenylation precedes enzymatic removal of the 5' cap, which then exposes the naked end to 5' exonuclease action. Here, we analyzed gene expression in Saccharomyces cerevisiae cells bearing conditional mutations of Ceg1 (capping enzyme), a 52 kDa protein that transfers GMP from GTP to the 5' end of mRNA to form the GpppN cap structure. Shift of ceg1 mutants to...

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Identifiers

PMID: 9547258
DOI: 10.1093/nar/26.9.2050
PMCID: PMC147543

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Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme.PMID 9547258Read ↗

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