Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran.

Science (New York, N.Y.) - 21 May 1999

Wilde A, Zheng Y

Abstract excerpt

Ran, a small guanosine triphosphatase, is suggested to have additional functions beyond its well-characterized role in nuclear trafficking. Guanosine triphosphate-bound Ran, but not guanosine diphosphate-bound Ran, stimulated polymerization of astral microtubules from centrosomes assembled on Xenopus sperm. Moreover, a Ran allele with a mutation in the effector domain (RanL43E) induced the formation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Extracts
Share to Centrosome
Share to Dimethyl Sulfoxide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dyneins

Share to Guanosine Diphosphate

Share to ran GTP-Binding Protein

Share to Xenopus Proteins

Source

Identifiers

PMID: 10334991
DOI: 10.1126/science.284.5418.1359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran.PMID 10334991Read ↗

The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.Semantic proximity Read ↗

Spatial and temporal coordination of mitosis by Ran GTPase.Semantic proximity Read ↗

Crm1 is a mitotic effector of Ran-GTP in somatic cells.Semantic proximity Read ↗

Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis.Semantic proximity Read ↗

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle lengthSemantic proximity Read ↗

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.Semantic proximity Read ↗

Subcellular localization and role of Ran1 in Tetrahymena thermophila amitotic macronucleus.Semantic proximity Read ↗

Dynamic localisation of Ran GTPase during the cell cycle.Semantic proximity Read ↗

Tumor Cell Dependence on Ran-GTP–Directed MitosisSemantic proximity Read ↗

Kinectin is a key effector of RhoG microtubule-dependent cellular activity.Semantic proximity Read ↗

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.Semantic proximity Read ↗

The fission yeast ran GTPase is required for microtubule integrity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.