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Article

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage.

Nature - 1 Jul 1999

Jimenez G S, Bryntesson F, Torres-Arzayus M I, Priestley A, Beeche M, Saito S, Sakaguchi K, Appella E, Jeggo P A, Taccioli G E, Wahl G M, Hubank M

Abstract excerpt

Damage to DNA in the cell activates the tumour-suppressor protein p53, and failure of this activation leads to genetic instability and a predisposition to cancer. It is therefore crucial to understand the signal transduction mechanisms that connect DNA damage with p53 activation. The enzyme known as DNA-dependent protein kinase (DNA-PK) has been proposed to be an essential activator of p53, but the evidence for...

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Identifiers

PMID: 10403253
DOI: 10.1038/21913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage.PMID 10403253Read ↗

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