Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.

The Journal of biological chemistry - 9 Apr 2004

Jack Melissa T, Woo Richard A, Motoyama Noboru, Takai Hitoyuki, Lee Patrick W K

Abstract excerpt

The role of the checkpoint kinase 2 (Chk2) as an upstream activator of p53 following DNA damage has been controversial. We have recently shown that Chk2 and the DNA-dependent protein kinase (DNA-PK) are both involved in DNA damage-induced apoptosis but not G(1) arrest in mouse embryo fibroblasts....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androstadienes
Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell-Free System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Checkpoint Kinase 2

Share to Cytoplasm

Share to DNA-Activated Protein Kinase

Share to G1 Phase

Share to Wortmannin

Source

Identifiers

PMID: 14752107
DOI: 10.1074/jbc.M309917200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14752107-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.PMID 14752107Read ↗

Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage ResponseSemantic proximity Read ↗

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.Semantic proximity Read ↗

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.Semantic proximity Read ↗

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage.Semantic proximity Read ↗

The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer CellsSemantic proximity Read ↗

Molecular mechanisms regulating the G2 checkpoint induced after DNA damageSemantic proximity Read ↗

Cdk2 kinase phosphorylates serine 315 of human p53 in vitro.Semantic proximity Read ↗

p38 Mitogen-Activated Protein Kinase Promotes Cell Survival in Response to DNA Damage but Is Not Required for the G2 DNA Damage Checkpoint in Human Cancer CellsSemantic proximity Read ↗

Negative Regulation of Chk2 Expression by p53 Is Dependent on the CCAAT-binding Transcription Factor NF-YSemantic proximity Read ↗

Chk2 activation and phosphorylation-dependent oligomerization.Semantic proximity Read ↗

Characterization of tumor-associated Chk2 mutations.Semantic proximity Read ↗

Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.