S phase cell-cycle arrest following DNA damage is independent of the p53/p21(WAF1) signalling pathway.

Article

S phase cell-cycle arrest following DNA damage is independent of the p53/p21(WAF1) signalling pathway.

Oncogene - 7 Mar 1996

Wyllie F S, Haughton M F, Bond J A, Rowson J M, Jones C J, Wynford-Thomas D

Abstract excerpt

It is now likely that the cyclin-kinase inhibitor, p21(WAF1/SD11), is a key effector of p53-mediated cell-cycle arrest at the G(1)/S checkpoint following DNA damage. More recently, however, in vitro data has suggested that this pathway may also mediate the acute inhibition of DNA synthesis seen i...

Topics

Antibiotics, Antineoplastic
Bleomycin
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA
DNA Damage
Humans
Interphase
Male
Mutation
S Phase
Signal Transduction
Tumor Suppressor Protein p53

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