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Article

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

24 Feb 1995

Abstract excerpt

The radiosensitive rodent mutant cell line xrs-5 is defective in DNA double-strand break repair and lacks the Ku component of the DNA-activated protein kinase, DNA-PK. Here radiosensitive human cell lines were analyzed for DNA-PK activity and for the presence of related proteins. The radiosensitive human malignant glioma M059J cell line was found to be defective in DNA double-strand break repair, but fails to...

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PMID: 7855602
DOI: 10.1126/science.7855602

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