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Article

Growth phase-dependent regulation of Vsr endonuclease may contribute to 5-methylcytosine mutational hot spots in Escherichia coli.

Journal of bacteriology - 1 Jul 1999

Macintyre G, Pitsikas P, Cupples C G

Abstract excerpt

Using rabbit polyclonal antibodies, we have shown that the Dcm cytosine methylase of Escherichia coli is maintained at a constant level during cell growth, while Vsr endonuclease levels are growth phase dependent. Decreased production of Vsr relative to Dcm during the log phase may contribute substantially to the mutability of 5-methylcytosine.

Topics

5-Methylcytosine
Cytosine
DNA (Cytosine-5-)-Methyltransferases
Endodeoxyribonucleases
Escherichia coli
Gene Expression Regulation, Bacterial
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10400606
DOI: 10.1128/JB.181.14.4435-4436.1999
PMCID: PMC93950

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