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A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen

20 Nov 2015

Abstract excerpt

DNA methylation is a key epigenetic regulator in all domains of life, yet the effects of most bacterial DNA methyltransferases on cellular processes are largely undefined. Here, we used diverse techniques, including bisulfite sequencing, transcriptomics, and transposon insertion site sequencing to extensively characterize a 5-methylcytosine (5mC) methyltransferase, VchM, in the cholera pathogen, Vibrio cholerae....

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PMID: 26588462
DOI: 10.1371/journal.pgen.1005666

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