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Article

A cell cycle-regulated bacterial DNA methyltransferase is essential for viability.

Proceedings of the National Academy of Sciences of the United States of America - 6 Feb 1996

Stephens C, Reisenauer A, Wright R, Shapiro L

Abstract excerpt

The CcrM adenine DNA methyltransferase, which specifically modifies GANTC sequences, is necessary for viability in Caulobacter crescentus. To our knowledge, this is the first example of an essential prokaryotic DNA methyltransferase that is not part of a DNA restriction/modification system. Homologs of CcrM are widespread in the alpha subdivision of the Proteobacteria, suggesting that methylation at GANTC sites...

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Identifiers

PMID: 8577742
DOI: 10.1073/pnas.93.3.1210
PMCID: PMC40058

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