Article
The Vsr endonuclease of Escherichia coli: an efficient DNA repair enzyme and a potent mutagen.
Journal of bacteriology - 1 Oct 1997
Macintyre G, Doiron K M, Cupples C G
Abstract excerpt
The Vsr endonuclease of Escherichia coli initiates the repair of T/G mismatches caused by deamination of 5-methylcytosine to thymine. In this paper, we examine the capacity of Vsr to prevent CG-to-TA mutations in cells with increased transcription of the cytosine methylase gene (dcm). We find tha...
Topics
- Adenosine Triphosphatases
- Bacterial Proteins
- Chromosomes, Bacterial
- DNA (Cytosine-5-)-Methyltransferases
- DNA Repair
- DNA Repair Enzymes
- DNA-Binding Proteins
- Endodeoxyribonucleases
- Escherichia coli
- Escherichia coli Proteins
- F Factor
- Frameshift Mutation
- MutL Proteins
- MutS DNA Mismatch-Binding Protein
- Mutation
- Operon
- Transformation, Bacterial