Isolation and characterization of an Escherichia coli strain with a high frequency of C-to-T mutations at 5-methylcytosines.

doi:10.1128/jb.175.16.4985-4989.1993

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Article

Isolation and characterization of an Escherichia coli strain with a high frequency of C-to-T mutations at 5-methylcytosines.

Journal of bacteriology - 1 Aug 1993

Ruiz S M, Létourneau S, Cupples C G

Abstract excerpt

We used a genetic selection system to isolate a strain of Escherichia coli with a high frequency of C-to-T transition mutations at the second C of the sequence CCAGG. Cytosines in other sequences do not mutate to thymine at a high frequency in this strain, and the frequencies of other base substi...

Topics

5-Methylcytosine
Base Sequence
Chromosome Mapping
Cytosine
DNA Repair
Escherichia coli
Genes, Bacterial
Lac Operon
Molecular Sequence Data
Mutagenesis
Phenotype
Suppression, Genetic
Thymine

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