Article
Discrimination by Escherichia coli initiation factor IF3 against initiation on non-canonical codons relies on complementarity rules.
Journal of molecular biology - 23 Jul 1999
Meinnel T, Sacerdot C, Graffe M, Blanquet S, Springer M
Abstract excerpt
Translation initiation factor IF3, one of three factors specifically required for translation initiation in Escherichia coli, inhibits initiation on any codon other than the three canonical initiation codons, AUG, GUG, or UUG. This discrimination against initiation on non-canonical codons could be due to either direct recognition of the two last bases of the codon and their cognate bases on the anticodon or to...
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