Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered discrimination of start codons and initiator tRNAs by mutant initiation factor 3.

RNA (New York, N.Y.) - 1 Jul 2001

O'Connor M, Gregory S T, Rajbhandary U L, Dahlberg A E

Abstract excerpt

IF3 is essential for ensuring the fidelity of the initiation step of translation in bacterial cells. Mutations at residues R99 and R131 in the C-terminal domain of the factor have previously been shown to increase initiation from the non-canonical GUA codon. Here we show that these mutant forms o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Codon, Initiator
Share to Eukaryotic Initiation Factor-3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Nucleic Acid Conformation

Share to Peptide Initiation Factors

Share to RNA, Transfer

Source

Open in PubMed Open full text

Identifiers

PMID: 11453069
DOI: 10.1017/s1355838201010184
PMCID: PMC1370149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11453069-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered discrimination of start codons and initiator tRNAs by mutant initiation factor 3.PMID 11453069Read ↗

A single mutation in the IF3 N-terminal domain perturbs the fidelity of translation initiation at three levels.Semantic proximity Read ↗

Discrimination by Escherichia coli initiation factor IF3 against initiation on non-canonical codons relies on complementarity rules.Semantic proximity Read ↗

IF2 and unique features of initiator tRNAfMet help establish the translational reading frame.Semantic proximity Read ↗

Escherichia coli translation initiation factor 3 discriminates the initiation codon in vivo.Semantic proximity Read ↗

The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH.Semantic proximity Read ↗

Mutations that alter initiation codon discrimination by Escherichia coli initiation factor IF3.Semantic proximity Read ↗

IF3-mediated suppression of a GUA initiation codon mutation in the recJ gene of Escherichia coli.Semantic proximity Read ↗

Characterization of 16S rRNA mutations that decrease the fidelity of translation initiation.Semantic proximity Read ↗

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.Semantic proximity Read ↗

Escherichia coli initiator tRNA: structure-function relationships and interactions with the translational machinery.Semantic proximity Read ↗

Mapping the active sites of bacterial translation initiation factor IF3.Semantic proximity Read ↗

Two highly conserved features of bacterial initiator tRNAs license them to pass through distinct checkpoints in translation initiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.