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Article

The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH.

The EMBO journal - 11 Jan 2006

Lomakin Ivan B, Shirokikh Nikolay E, Yusupov Marat M, Hellen Christopher U T, Pestova Tatyana V

Abstract excerpt

Eukaryotic initiation factor eIF1 and the functional C-terminal domain of prokaryotic initiation factor IF3 maintain the fidelity of initiation codon selection in eukaryotes and prokaryotes, respectively, and bind to the same regions of small ribosomal subunits, between the platform and initiator tRNA. Here we report that these nonhomologous factors can bind to the same regions of heterologous subunits and...

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Identifiers

PMID: 16362046
DOI: 10.1038/sj.emboj.7600904
PMCID: PMC1356347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH.PMID 16362046Read ↗

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