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Article

Unconventional initiator tRNAs sustain Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 7 Aug 2012

Samhita Laasya, Shetty Sunil, Varshney Umesh

Abstract excerpt

Of all tRNAs, initiator tRNA is unique in its ability to start protein synthesis by directly binding the ribosomal P-site. This ability is believed to derive from the almost universal presence of three consecutive G-C base (3G-C) pairs in the anticodon stem of initiator tRNA. Consistent with the hypothesis, a plasmid-borne initiator tRNA with one, two, or all 3G-C pairs mutated displays negligible initiation...

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Share to Anticodon
Share to Base Pairing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22829667
DOI: 10.1073/pnas.1207868109
PMCID: PMC3420168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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