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Article

Involvement of 16S rRNA nucleotides G1338 and A1339 in discrimination of initiator tRNA.

Molecular cell - 23 Nov 2005

Lancaster Laura, Noller Harry F

Abstract excerpt

Three consecutive G-C pairs in the anticodon stem are a key discriminatory feature of initiator tRNA and are required for its selection by IF3. Here, we have mutated two 16S rRNA nucleotides, G1338 and A1339, which provide the sole contact to the G-C pairs of tRNA(fMet) bound to the ribosomal P site. We have tested their effects on translational activities in vivo and have affinity-purified mutant 30S subunits...

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Identifiers

PMID: 16307925
DOI: 10.1016/j.molcel.2005.10.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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