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Article

Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jun 1997

Miret J J, Pessoa-Brandão L, Lahue R S

Abstract excerpt

A quantitative genetic assay was developed to monitor alterations in tract lengths of trinucleotide repeat sequences in Saccharomyces cerevisiae. Insertion of (CAG)50 or (CTG)50 repeats into a promoter that drives expression of the reporter gene ADE8 results in loss of expression and white colony color. Contractions within the trinucleotide sequences to repeat lengths of 8 to 38 restore functional expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9154837
DOI: 10.1128/MCB.17.6.3382
PMCID: PMC232191

Genes

MSH2
MSH3
PMS1
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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