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Article

Expansion and Length-Dependent Fragility of CTG Repeats in Yeast

6 Feb 1998

Abstract excerpt

Expansion of DNA trinucleotide repeats (TNRs) is the causative mutation in a growing number of human genetic diseases. Large expansions of a CTG tract were obtained and shown by genetic and physical assays to be length-dependent sites of chromosome breakage in Saccharomyces cerevisiae. Deletion of RAD27, which encodes a nuclease involved in Okazaki fragment processing, caused length-dependent destabilization of...

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PMID: 9452383
DOI: 10.1126/science.279.5352.853

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Expansion and Length-Dependent Fragility of CTG Repeats in YeastPMID 9452383Read ↗

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