Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.

doi:10.1016/s0959-440x(98)80065-1

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Article

Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.

Current opinion in structural biology - 1 Jun 1998

Pearson C E, Sinden R R

Abstract excerpt

Models for the disease-associated expansion of (CTG)n.(CAG)n, (CGG)n.(CCG)n, and (GAA)n.(TTC)n trinucleotide repeats involve alternative DNA structures formed during DNA replication, repair and recombination. These repeat sequences are inherently flexible and can form a variety of hairpins, intra...

Topics

Base Composition
Base Sequence
DNA
DNA Repair
DNA Replication
Genetic Diseases, Inborn
Humans
Models, Genetic
Models, Molecular
Mutation
Nucleic Acid Conformation
Recombination, Genetic
Thermodynamics
Trinucleotide Repeats

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